Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide-alkyne cycloadditions.

نویسندگان

  • William D G Brittain
  • Benjamin R Buckley
  • John S Fossey
چکیده

The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to 22.1 ± 0.5 are reported. Enantioenriched alkynes and triazoles were obtained in ≥80% enantiomeric excess (e.e.).

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عنوان ژورنال:
  • Chemical communications

دوره 51 97  شماره 

صفحات  -

تاریخ انتشار 2015